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SSF Vesicle Lab

Swedish Center for Acoustofluidics and Cell Separation

This project is financed by the Swedish Foundation for Strategic Research from the call of 2013: Synergy. The project runs between 2014 and 2019 (total five years) and is led by Professor Thomas Laurell, Lund University. The project is conducted in a research environment comprising the following group leaders: Professors Hans Lilja (LU/MSKCC/Oxford); Stefan Scheding (Skane University Hospitals); and David Erlinge (Skane University Hospitals/Lund University). We want to work together to characterize microvesicles and similar in prostate cancer, cardiovascular disease, and stem cell cultures.

Thomas Laurell (LU, project leader). Microvesicles can contain disease markers, that are cumbersome to isolate using ultracentrifugation. Acoustic trapping of sub-micrometer vesicles can be used to streamline the process.

Hans Lilja (LU/Oxford/MSKCC). Several biomarkers in the prostate have high diagnostic and prognostic potential, but better, non-invasive study methods are needed. Total exosomal RNA is increased in prostate cancer patients compared to healthy men.

David Erlinge (LU/SUS). There are three main drivers of cardiovascular disease development: endothelial dysfunction, inflammation, and platelet activation. All three processes release microparticles to communicate and regulate cardiovascular physiology.

Stefan Scheding (SUS). The positive effects of stem cell therapy are due to the released cytokines and chemokines from the administered cells, acting in paracrine fashion. Activated stem cells also produce microvesicles that can reprogram neighboring cells. Photo: Katarina Branzén.


SSF Vesicle Lab

Detta projekt finansieras av Stiftelsen för Strategisk Forskning (SSF) inom utlysningen 2013: Synergy.
Projektet löper mellan 2014 och 2019 (totalt fem år) och leds av Professor Thomas Laurell, Lunds Universitet. Projektet utförs inom en forskningsmiljö där dessa gruppledare ingår: Professorerna Hans Lilja (LU/MSKCC/Oxford); Stefan Scheding (Region Skåne) och David Erlinge (Region Skåne/LU). Tillsammans vill vi kartlägga och undersöka mikrovesiklar och liknande inom prostatacancer, hjärt-kärlsjukdomar och stamcellskulturer.