The project Lab-on-a-chip microvesicle diagnosis for clinical use (or Vesicle Lab for short), was funded by the Swedish Foundation for Strategic Research (SSF) during the years 2014-2020.
Thomas Laurell (LU, project leader). Microvesicles can contain disease markers that are cumbersome to isolate using ultracentrifugation. Acoustic trapping of sub-micrometer vesicles can be used to streamline the process.
Hans Lilja (LU/Oxford/MSKCC). Several biomarkers in the prostate have high diagnostic and prognostic potential, but better, non-invasive study methods are needed. Total exosomal RNA is increased in prostate cancer patients compared to healthy men.
David Erlinge (LU/SUS). There are three mail drivers of cardiovascular disease development: endothelial dysfunction, inflammation, and platelet activation. All three processes release microparticles to communicate and regulate cardiovascular physiology.
Stefan Scheding (SUS). The positive effects of stem cell therapy are due to the released cytokines and chemokines from the administered cells, acting in paracrine fashion. Activated stem cells also produce microvesicles that can reprogram neighboring cells. Photo: Katarina Branzen.