Thomas Laurell (LU, project leader). Ultrasonic waves can sort different cell types based on their specific aucoustic fingerprints. This technology called acoustophoresis enables gentle and precise cell sorting for downstream bioanalytical and preparatory experiments. Thomas Laurell lead this KAW-funded center grant comprising four major tasks.

Henrik Bruus (DTU). Acoustophoretic microchips were traditionally developed by trial and error. In collaboration with Henrik Bruus, DTU, we aim for rational design by developing novel mathematical models for in silico analyses of the acoustic 3D resonance patterns of acoustophoresis chip designs.

David Erlinge (LU/SUS). In the treatment of cardiovascular disorders it is crucial to be able to measure the response of red blood cells to drugs in real time. In collaboration with David Erlinge we develop ultrasonic tweezers, enabling unbiased response studies of red blood cells in their quiescent state as a function of molecular stimuli.

Hans Lilja (LU/MSKCC/Oxford). A major problem in all cancers is detecting the circulating tumor cells, that can migrate and metastasize at random locations in the body. In collaboration with Hans Lilja we develop acoustophoresis for label-free isolation, and molecular analysis of prostate cancer cells spread to the blood circulation. 

David Ulmert (LU/MSKCC). David Ulmert develops novel antibody-directed PET markers based on zirconium-89-conjugated monoclonal antibodies against prostate-specific antigen (PSA) or kallikrinein-related peptidases in order to detect spreading prostate cancer with high resolution.